Is Salvia Divinorum really a hallucinogenic herb?

September 21, 2008 by Admin
Filed under: Salvia Divinorum 

There’s a lot of hype about Salvia Divinorum these days and it’s powers of being a hallucinogenic herb. Salvia divinorum is quite a widespread and well known hallucinogenic herb traditionally used for divination and meditation, as well as a medicinal cure for several disorders including disturbances of gastrointestinal motility etc. however that was something that it was used for a long time ago.

In a recent study, the effect of a standardized extract from the leaves of Salvia divinorum (SDE) on enteric cholinergic transmission in the guinea-pig ileum was evaluated. Salvia Divinorum extract actually reduced electrically evoked contractions and that too modifying the contractions elicited by exogenous acetylcholine, thus suggesting a prejunctional site of action.

The inhibitory effect of Salvia Divinorum Extract on twitch response was abolished by the opioid receptor antagonist naloxone and also by the kappa-opioid antagonist nor-binaltorphimine, but not by naltrindole (a delta-opioid receptor antagonist), CTOP (a mu-opioid receptor antagonist), thioperamide (a H(3) receptor antagonist), yohimbine (an alpha(2)-receptor antagonist), methysergide (a 5-hydroxytryptamine receptor antagonist), N(G)-nitro-l-arginine methyl ester (an inhibitor of NO synthase) or apamin (a blocker of Ca(2+)-activated K(+) channels). Salvinorin A, the main active ingredient of the Salvia divinorum, inhibited in a nor-binaltorphimine- and naloxone-sensitive manner electrically induced contractions.

Through all these studies, tests and experiments it is now concluded that Salvia Divinorum Extract depressed enteric cholinergic transmission likely through activation of kappa-opioid receptors and this may provide the pharmacological basis underlying its traditional antidiarrhoeal use. Salvinorin A might be the chemical ingredient responsible for this activity.

Hence salvia Divinorum is a hallucinogenic herb that can give out – of – body experiences to the user.

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Comments

2 Comments on Is Salvia Divinorum really a hallucinogenic herb?

  1. Vital Acai on Mon, 2nd Feb 2009 11:53 am

    2. Also try Vital acai, it is beneficial for a good night’s sleep. The Amino acids contained in the acai relax the muscles and thus result in a peaceful sleep.

  2. auto glass repair on Mon, 16th Mar 2009 6:59 pm

    3. has it already been used my many as i haven’t seen much info on this

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