Is Salvia Divinorum really a hallucinogenic herb?
There’s a lot of hype about Salvia Divinorum these days and it’s powers of being a hallucinogenic herb. Salvia divinorum is quite a widespread and well known hallucinogenic herb traditionally used for divination and meditation, as well as a medicinal cure for several disorders including disturbances of gastrointestinal motility etc. however that was something that it was used for a long time ago.
In a recent study, the effect of a standardized extract from the leaves of Salvia divinorum (SDE) on enteric cholinergic transmission in the guinea-pig ileum was evaluated. Salvia Divinorum extract actually reduced electrically evoked contractions and that too modifying the contractions elicited by exogenous acetylcholine, thus suggesting a prejunctional site of action.
The inhibitory effect of Salvia Divinorum Extract on twitch response was abolished by the opioid receptor antagonist naloxone and also by the kappa-opioid antagonist nor-binaltorphimine, but not by naltrindole (a delta-opioid receptor antagonist), CTOP (a mu-opioid receptor antagonist), thioperamide (a H(3) receptor antagonist), yohimbine (an alpha(2)-receptor antagonist), methysergide (a 5-hydroxytryptamine receptor antagonist), N(G)-nitro-l-arginine methyl ester (an inhibitor of NO synthase) or apamin (a blocker of Ca(2+)-activated K(+) channels). Salvinorin A, the main active ingredient of the Salvia divinorum, inhibited in a nor-binaltorphimine- and naloxone-sensitive manner electrically induced contractions.
Through all these studies, tests and experiments it is now concluded that Salvia Divinorum Extract depressed enteric cholinergic transmission likely through activation of kappa-opioid receptors and this may provide the pharmacological basis underlying its traditional antidiarrhoeal use. Salvinorin A might be the chemical ingredient responsible for this activity.
Hence salvia Divinorum is a hallucinogenic herb that can give out – of – body experiences to the user.
Benefits of Salvia divinorum
Solid scientific research, published in the Proceedings of the National Academy of the Sciences (USA), suggests that salvia is a hallucinogen and over and above that, it does not act in any way similar to the drug: LSD, but it actually can stop hallucinations caused by certain disorders and diseases like:
- Alzheimer’s,
- Huntington’s disease,
- Pick’s disease,
- Long-term cocaine use, and
- Long-term use of methamphetamines.
Now you’d be confused and ask yourself how can it possibly be capable of doing such a thing, so here’s the explanation:
Firstly, it is extremely important for us to know that scientists know what they know about Salvia divinorum by testing it on lab rats and guinea pigs. Moreover, they started their studies by injecting extracts of the herb directly into the brains of these rats that they carry out their tests and experiments on. (And since I’ve learned you have to make this sort of thing clear, there are absolutely, positively no circumstances I would in any way support intracranial administration of any herb in humans.) It’s only since the last one year that scientists have begun testing the effects of the herb salvia Divinorum as it is taken orally, and that’s right, it is once again tested with the help of rats.
But in this context, what the scientists have discovered about salvia is quite remarkable and does require acknowledgement. It acts in a way different from almost every other psychotropic drug investigated to date. It stimulates the opioid receptors of the brain. Salvia Divinorum is different from any other drug ever know to manking, it is one of a kind, it is unique!
When we talk about the opioid receptors, we are talking about the same sites on brain cells that respond to morphine. Activating opioid receptors blocks pain. These are also the sites inside the brain that create the well-known “runner’s high.” There is something about reaching a predetermined goal through effort, whether it’s running a course, winning a game through physical effort, or enduring non-injurious pain (such acupuncture) that causes stress hormones to enter the brain instantly and start flooding it which results to be converted to endorphins. And, of course, endorphins are also released by orgasm as you would have already guessed.
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